Illnesses caused by influenza virus infection are difficult to
distinguish from illnesses caused by other respiratory pathogens
based on symptoms alone. Young children are less likely to have
typical influenza symptoms (e.g., fever and cough) and infants
may present to medical care with fever and lethargy, and may not
have cough or other respiratory symptoms or signs.
Influenza-associated deaths among children, while uncommon, do
occur with seasonal influenza with an estimated average of
approximately 92 influenza-related pediatric deaths each year in
the United States. Some deaths in children have been associated
with co-infection with influenza and Staphylococcus aureus,
particularly methicillin resistant S. aureus (MRSA).